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K. Funakoshi, T. Morita, A. Kumanogoh, Longer Prehospitalization and Preintubation Periods in Intubated Non-survivors and ECMO Patients With COVID-19: A Systematic Review and Meta-Analysis. Front Med (Lausanne). 8, 727101 (2021).

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J. Kano, N. Koizumi, A. Terada, A. Matsuoka, T. Hirai, T. Nomura, H. Mizuguchi, N. Utoguchi, Fiber-Knob Region of Adenovirus Type 5 Vector Promotes Migration of A549 Cells. BPB Reports. 4, 17–21 (2021).

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T. Kawano, T. Sasaki, Y. Gon, T. Kitano, H. Kanki, K. Todo, M. Shimamura, Y. Matsumura, A. Huang, S. Hattori, H. Mochizuki, High neutrophil/lymphocyte ratio at cancer diagnosis predicts incidence of stroke in cancer patients. Brain Commun. 3, fcab071 (2021).

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F. Sakurai, T. Tsukamoto, R. Ono, F. Nishimae, A. Shiota, S. Iizuka, K. Shimizu, E. Sakai, Y. Ishida, C. Tateno, K. Chayama, H. Mizuguchi, Transduction Properties of an Adenovirus Vector Containing Sequences Complementary to a Liver-Specific microRNA, miR-122a, in the 3’-Untranslated Region of the E4 Gene in Human Hepatocytes from Chimeric Mice with Humanized Liver. Biol Pharm Bull. 44, 1506–1513 (2021).

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M. Yagita, T. Morita, A. Kumanogoh, Therapeutic efficacy of denosumab for rheumatoid arthritis: a systematic review and meta-analysis. Rheumatol Adv Pract. 5, rkab099 (2021).

6.

K. Baba, N. Hashida, M. Tujikawa, A. J. Quantock, K. Nishida, The generation of fluorometholone nanocrystal eye drops, their metabolization to dihydrofluorometholone and penetration into rabbit eyes. Int J Pharm. 592, 120067 (2021).

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B. M. Lin, K. E. Grinde, J. A. Brody, C. E. Breeze, L. M. Raffield, J. C. Mychaleckyj, T. A. Thornton, J. A. Perry, L. J. Baier, L. de Las Fuentes, X. Guo, B. D. Heavner, R. L. Hanson, Y.-J. Hung, H. Qian, C. A. Hsiung, S.-J. Hwang, M. R. Irvin, D. Jain, T. N. Kelly, S. Kobes, L. Lange, J. P. Lash, Y. Li, X. Liu, X. Mi, S. K. Musani, G. J. Papanicolaou, A. Parsa, A. P. Reiner, S. Salimi, W. H.-H. Sheu, A. R. Shuldiner, K. D. Taylor, A. V. Smith, J. A. Smith, A. Tin, D. Vaidya, R. B. Wallace, K. Yamamoto, S. Sakaue, K. Matsuda, Y. Kamatani, Y. Momozawa, L. R. Yanek, B. A. Young, W. Zhao, Y. Okada, G. Abecasis, B. M. Psaty, D. K. Arnett, E. Boerwinkle, J. Cai, I. Yii-Der Chen, A. Correa, L. A. Cupples, J. He, S. L. Kardia, C. Kooperberg, R. A. Mathias, B. D. Mitchell, D. A. Nickerson, S. T. Turner, R. S. Vasan, J. I. Rotter, D. Levy, H. J. Kramer, A. Köttgen, null Nhlbi Trans-Omics For Precision Medicine TOPMed Consortium, null TOPMed Kidney Working Group, S. S. Rich, D.-Y. Lin, S. R. Browning, N. Franceschini, Whole genome sequence analyses of eGFR in 23,732 people representing multiple ancestries in the NHLBI trans-omics for precision medicine (TOPMed) consortium. EBioMedicine. 63, 103157 (2021).

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T. Kishikawa, Y. Maeda, T. Nii, N. Arase, J. Hirata, K. Suzuki, K. Yamamoto, T. Masuda, K. Ogawa, S. Tsuji, M. Matsushita, H. Matsuoka, M. Yoshimura, S. Tsunoda, S. Ohshima, M. Narazaki, A. Ogata, Y. Saeki, H. Inohara, A. Kumanogoh, K. Takeda, Y. Okada, Increased levels of plasma nucleotides in patients with rheumatoid arthritis. Int Immunol. 33, 119–124 (2021).

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E. G. Atkinson, A. X. Maihofer, M. Kanai, A. R. Martin, K. J. Karczewski, M. L. Santoro, J. C. Ulirsch, Y. Kamatani, Y. Okada, H. K. Finucane, K. C. Koenen, C. M. Nievergelt, M. J. Daly, B. M. Neale, Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power. Nat Genet. 53, 195–204 (2021).

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C. Kogame-Asahara, H. Iguchi, K. Honda, H. Shigemitsu, T. Kida, Terminal Trialkylsilyl Substituent Effect of Janus-type Molecular Tubes on the Inclusion of Unsaturated Fatty Acid Esters. ACS Omega. 6, 3227–3231 (2021).

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S. Sakaue, E. Yamaguchi, Y. Inoue, M. Takahashi, J. Hirata, K. Suzuki, S. Ito, T. Arai, M. Hirose, Y. Tanino, T. Nikaido, T. Ichiwata, S. Ohkouchi, T. Hirano, T. Takada, S. Miyawaki, S. Dofuku, Y. Maeda, T. Nii, T. Kishikawa, K. Ogawa, T. Masuda, K. Yamamoto, K. Sonehara, R. Tazawa, K. Morimoto, M. Takaki, S. Konno, M. Suzuki, K. Tomii, A. Nakagawa, T. Handa, K. Tanizawa, H. Ishii, M. Ishida, T. Kato, N. Takeda, K. Yokomura, T. Matsui, M. Watanabe, H. Inoue, K. Imaizumi, Y. Goto, H. Kida, T. Fujisawa, T. Suda, T. Yamada, Y. Satake, H. Ibata, N. Hizawa, H. Mochizuki, A. Kumanogoh, F. Matsuda, K. Nakata, T. Hirota, M. Tamari, Y. Okada, Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis. Nat Commun. 12, 1032 (2021).

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M. Ichikawa, R. Negoro, K. Kawai, T. Yamashita, K. Takayama, H. Mizuguchi, Vinblastine treatment decreases the undifferentiated cell contamination of human iPSC-derived intestinal epithelial-like cells. Mol Ther Methods Clin Dev. 20 463–472 (2021).

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S. Kusumoto, M. Kurashige, K. Ohshima, S. Tahara, T. Matsui, S. Nojima, S. Hattori, E. Morii, An immature inhibin-α-expressing subpopulation of ovarian clear cell carcinoma cells is related to an unfavorable prognosis. Cancer Med. 10, 1485–1500 (2021).

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K. Maruyama, K. Yoneda, S. Sugita, Y. Yamamoto, M. Koike, C. Peters, Y. Uchiyama, K. Nishida, CTLA-2 Alpha Is a Potent Inhibitor of Angiogenesis in Murine Ocular Tissue. Antioxidants (Basel). 10, 456 (2021).

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R. Ono, K. Takayama, F. Sakurai, H. Mizuguchi, Efficient antitumor effects of a novel oncolytic adenovirus fully composed of species B adenovirus serotype 35. Mol Ther Oncolytics. 20, 399–409 (2021).

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K. Sonehara, Y. Okada, Genomics-driven drug discovery based on disease-susceptibility genes. Inflamm Regen. 41, 8 (2021).

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H. S.-C. Wong, C.-L. Guo, G.-H. Lin, K.-Y. Lee, Y. Okada, W.-C. Chang, Transcriptome network analyses in human coronavirus infections suggest a rational use of immunomodulatory drugs for COVID-19 therapy. Genomics. 113, 564–575 (2021).

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T. Morimoto, T. Fujikado, H. Kanda, T. Miyoshi, T. Endo, K. Nishida, H. Kishima, T. Saito, K. Ito, M. Ozawa, K. Nishida, Testing of Newly Developed Wide-Field Dual-Array Suprachoroidal-Transretinal Stimulation Prosthesis in Dogs. Transl Vis Sci Technol. 10, 13 (2021).

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T. Naito, K. Suzuki, J. Hirata, Y. Kamatani, K. Matsuda, T. Toda, Y. Okada, A deep learning method for HLA imputation and trans-ethnic MHC fine-mapping of type 1 diabetes. Nat Commun. 12, 1639 (2021).

21.

W.-Y. Chee, Y. Kurahashi, J. Kim, K. Miura, D. Okuzaki, T. Ishitani, K. Kajiwara, S. Nada, H. Okano, M. Okada, β-catenin-promoted cholesterol metabolism protects against cellular senescence in naked mole-rat cells. Commun Biol. 4, 357 (2021).

22.

K. Sonehara, Y. Okada, Obelisc: an identical-by-descent mapping tool based on SNP streak. Bioinformatics. 36, 5567–5570 (2021).

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T. Konuma, K. Ogawa, Y. Okada, Integration of genetically regulated gene expression and pharmacological library provides therapeutic drug candidates. Hum Mol Genet. 30, 294–304 (2021).

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S. Ando, N. Hashida, D. Yamashita, T. Kawabata, K. Asao, S. Kawasaki, K. Sakurai, T. Yoshimori, K. Nishida, Rubicon regulates A2E-induced autophagy impairment in the retinal pigment epithelium implicated in the pathology of age-related macular degeneration. Biochem Biophys Res Commun. 551, 148–154 (2021).

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I. Ishigami, N. Shuwari, T. Kaminade, H. Mizuguchi, F. Sakurai, A TGFβ Signaling Inhibitor, SB431542, Inhibits Reovirus-mediated Lysis of Human Hepatocellular Carcinoma Cells in a TGFβ-independent Manner. Anticancer Res. 41, 2431–2440 (2021).

26.

J. I. Kim, T. Nakahama, R. Yamasaki, P. H. Costa Cruz, T. Vongpipatana, M. Inoue, N. Kanou, Y. Xing, H. Todo, T. Shibuya, Y. Kato, Y. Kawahara, RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain. PLoS Genet. 17, e1009516 (2021).

27.

T. Kishikawa, N. Arase, S. Tsuji, Y. Maeda, T. Nii, J. Hirata, K. Suzuki, K. Yamamoto, T. Masuda, K. Ogawa, S. Ohshima, H. Inohara, A. Kumanogoh, M. Fujimoto, Y. Okada, Large-scale plasma-metabolome analysis identifies potential biomarkers of psoriasis and its clinical subtypes. J Dermatol Sci. 102, 78–84 (2021).

28.

K. Nishida, S. Takahashi, H. Sakaguchi, S. Sato, M. Kanai, A. Shiraki, T. Wakabayashi, C. Hara, Y. Fukushima, S. Sakimoto, K. Sayanagi, R. Kawasaki, K. Nishida, Impact of photoreceptor density in a 3D simulation of panretinal laser photocoagulation. BMC Ophthalmol. 21, 200 (2021).

29.

N. Pirastu, M. Cordioli, P. Nandakumar, G. Mignogna, A. Abdellaoui, B. Hollis, M. Kanai, V. M. Rajagopal, P. D. B. Parolo, N. Baya, C. E. Carey, J. Karjalainen, T. D. Als, M. D. Van der Zee, F. R. Day, K. K. Ong, FinnGen Study, 23andMe Research Team, iPSYCH Consortium, T. Morisaki, E. de Geus, R. Bellocco, Y. Okada, A. D. Børglum, P. Joshi, A. Auton, D. Hinds, B. M. Neale, R. K. Walters, M. G. Nivard, J. R. B. Perry, A. Ganna, Genetic analyses identify widespread sex-differential participation bias. Nat Genet. 53, 663–671 (2021).

30.

T. Konuma, Y. Okada, Statistical genetics and polygenic risk score for precision medicine. Inflamm Regen. 41, 18 (2021).

31.

J. Nakata, K. Isohashi, Y. Oka, H. Nakajima, S. Morimoto, F. Fujiki, Y. Oji, A. Tsuboi, A. Kumanogoh, N. Hashimoto, J. Hatazawa, H. Sugiyama, Imaging Assessment of Tumor Response in the Era of Immunotherapy. Diagnostics (Basel). 11, 1041 (2021).

32.

M. Ichikawa, H. Akamine, M. Murata, S. Ito, K. Takayama, H. Mizuguchi, Generation of tetracycline-controllable CYP3A4-expressing Caco-2 cells by the piggyBac transposon system. Sci Rep. 11, 11670 (2021).

33.

T. Nakatani, K. Tsujimoto, J. Park, T. Jo, T. Kimura, Y. Hayama, H. Konaka, T. Morita, Y. Kato, M. Nishide, S. Koyama, S. Nada, M. Okada, H. Takamatsu, A. Kumanogoh, The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II. Nat Commun. 12, 3333 (2021).

34.

Q. S. Wang, D. R. Kelley, J. Ulirsch, M. Kanai, S. Sadhuka, R. Cui, C. Albors, N. Cheng, Y. Okada, Biobank Japan Project, F. Aguet, K. G. Ardlie, D. G. MacArthur, H. K. Finucane, Leveraging supervised learning for functionally informed fine-mapping of cis-eQTLs identifies an additional 20,913 putative causal eQTLs. Nat Commun. 12, 3394 (2021).

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C.-C. Hsu, R. Okumura, D. Motooka, R. Sasaki, S. Nakamura, T. Iida, K. Takeda, Alleviation of colonic inflammation by Lypd8 in a mouse model of inflammatory bowel disease. Int Immunol. 33, 359–372 (2021).

36.

T. Kawasaki, F. Sugihara, K. Fukushima, T. Matsuki, H. Nabeshima, T. Machida, Y. Mitsui, S. Fujimura, R. Sagawa, L. Gaheun, K. Kuniyoshi, H. Tanaka, M. Narazaki, A. Kumanogoh, S. Akira, T. Satoh, Loss of FCHSD1 leads to amelioration of chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A. 118, e2019167118 (2021).

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S. Kameoka, D. Motooka, S. Watanabe, R. Kubo, N. Jung, Y. Midorikawa, N. O. Shinozaki, Y. Sawai, A. K. Takeda, S. Nakamura, Benchmark of 16S rRNA gene amplicon sequencing using Japanese gut microbiome data from the V1-V2 and V3-V4 primer sets. BMC Genomics. 22, 527 (2021).

38.

Y. Maeda, T. Hirano, K. Ebina, R. Hara, M. Hashimoto, W. Yamamoto, K. Murakami, T. Kotani, K. Hata, Y. Son, H. Amuro, A. Onishi, S. Jinno, M. Katayama, A. Kumanogoh, Comparison of efficacy between anti-IL-6 receptor antibody and other biological disease-modifying antirheumatic drugs in the patients with rheumatoid arthritis who have knee joint involvement: the ANSWER cohort, retrospective study. Rheumatol Int. 41, 1233–1241 (2021).

39.

T. Nakae, M. Obana, T. Maeda, A. Ikeda, H. Miyazaki, S. Tanaka, M. Maeda, K. Yamashita, K. Terai, S. Obika, Y. Fujio, Title: Gene transfer by pyro-drive jet injector is a novel therapeutic approach for muscle diseases. Gene. 788, 145664 (2021).

40.

T. Wahyuni, A. Kobayashi, S. Tanaka, Y. Miyake, A. Yamamoto, A. Bahtiar, S. Mori, Y. Kametani, M. Tomimatsu, K. Matsumoto, M. Maeda, M. Obana, Y. Fujio, Maresin-1 induces cardiomyocyte hypertrophy through IGF-1 paracrine pathway. Am J Physiol Cell Physiol. 321, C82–C93 (2021).

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S. Deguchi, T. Shintani, K. Harada, T. Okamoto, A. Takemura, K. Hirata, K. Ito, K. Takayama, H. Mizuguchi, In Vitro Model for a Drug Assessment of Cytochrome P450 Family 3 Subfamily A Member 4 Substrates Using Human Induced Pluripotent Stem Cells and Genome Editing Technology. Hepatol Commun. 5, 1385–1399 (2021).

42.

T. Naito, W. Satake, K. Ogawa, K. Suzuki, J. Hirata, J. N. Foo, E.-K. Tan, T. Toda, Y. Okada, Trans-Ethnic Fine-Mapping of the Major Histocompatibility Complex Region Linked to Parkinson’s Disease. Mov Disord. 36, 1805–1814 (2021).

43.

S. Takahashi, K. Nishida, H. Sakaguchi, K. Nishida, A Case of Idiopathic Dense Vitreous Hemorrhage: Suspected Rupture of a Large Retinal Arterial Macroaneurysm on the Optic Disc. Case Rep Ophthalmol. 12, 634–639 (2021).

44.

T. Yamamuro, S. Nakamura, Y. Yamano, T. Endo, K. Yanagawa, A. Tokumura, T. Matsumura, K. Kobayashi, H. Mori, Y. Enokidani, G. Yoshida, H. Imoto, T. Kawabata, M. Hamasaki, A. Kuma, S. Kuribayashi, K. Takezawa, Y. Okada, M. Ozawa, S. Fukuhara, T. Shinohara, M. Ikawa, T. Yoshimori, Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function. PLoS Genet. 17, e1009688 (2021).

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J. Yokota, T. Yamashita, T. Inui, R. Nomoto, W. Kishimoto, H. Nakase, H. Mizuguchi, Comparison of culture media for human intestinal organoids from the viewpoint of pharmacokinetic studies. Biochem Biophys Res Commun. 566, 115–122 (2021).

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M. Henmi, S. Hattori, T. Friede, A confidence interval robust to publication bias for random-effects meta-analysis of few studies. Res Synth Methods. 12, 674–679 (2021).

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A. Huang, S. Komukai, T. Friede, S. Hattori, Using clinical trial registries to inform Copas selection model for publication bias in meta-analysis. Res Synth Methods. 12, 658–673 (2021).

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T. Wakabayashi, R. Kamuro, N. Hashida, N. Shiraki, H. Sakaguchi, N. Ohguro, K. Nishida, Acute endophthalmitis and hyphema mimicking pink hypopyon associated with ocular toxocariasis: A case report. Am J Ophthalmol Case Rep. 23, 101188 (2021).

49.

T. Yamashita, T. Inui, J. Yokota, K. Kawakami, G. Morinaga, M. Takatani, D. Hirayama, R. Nomoto, K. Ito, Y. Cui, S. Ruez, K. Harada, W. Kishimoto, H. Nakase, H. Mizuguchi, Monolayer platform using human biopsy-derived duodenal organoids for pharmaceutical research. Mol Ther Methods Clin Dev. 22, 263–278 (2021).

50.

M. Nakatochi, Y. Toyoda, M. Kanai, A. Nakayama, Y. Kawamura, A. Hishida, H. Mikami, K. Matsuo, T. Takezaki, Y. Momozawa, T. B. J. Project, Y. Kamatani, S. Ichihara, N. Shinomiya, M. Yokota, K. Wakai, Y. Okada, H. Matsuo, Japan Uric Acid Genomics Consortium (Japan Urate), An X chromosome-wide meta-analysis based on Japanese cohorts revealed that non-autosomal variations are associated with serum urate. Rheumatology (Oxford). 60, 4430–4432 (2021).

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Y. Suga, I. Nagatomo, Y. Kinehara, S. Koyama, D. Okuzaki, A. Osa, Y. Naito, H. Takamatsu, M. Nishide, S. Nojima, D. Ito, T. Tsuda, T. Nakatani, Y. Nakanishi, Y. Futami, T. Koba, S. Satoh, Y. Hosono, K. Miyake, K. Fukushima, T. Shiroyama, K. Iwahori, H. Hirata, Y. Takeda, A. Kumanogoh, IL-33 Induces Sema4A Expression in Dendritic Cells and Exerts Antitumor Immunity. J Immunol. 207, 1456–1467 (2021).

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T. Nakahama, Y. Kato, T. Shibuya, M. Inoue, J. I. Kim, T. Vongpipatana, H. Todo, Y. Xing, Y. Kawahara, Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy. Immunity. 54, 1976-1988.e7 (2021).

53.

Y. Miyake, M. Obana, T. Nakae, A. Yamamoto, S. Tanaka, M. Maeda, Y. Okada, Y. Fujio, PKNOX2 regulates myofibroblast functions and tubular cell survival during kidney fibrosis. Biochem Biophys Res Commun. 571, 88–95 (2021).

54.

H. Tani, B. Li, T. Kusu, R. Okumura, J. Nishimura, D. Okuzaki, D. Motooka, S. Arakawa, A. Mori, T. Yoshihara, T. Ogino, S.-H. Tsai, Y. Furuta, M. Muneta, S. Nakamura, E. Fukusaki, K. Yamamoto, H. Yagita, H. Kayama, K. Takeda, The ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis through modulation of P2X4 receptor-dependent metabolism in myeloid cells. Proc Natl Acad Sci U S A. 118, e2100594118 (2021).

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A. Harada, S. Matsumoto, Y. Yasumizu, K. Shojima, T. Akama, H. Eguchi, A. Kikuchi, Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion. Elife. 10, e66721 (2021).

56.

K. Fukushima, S. Kitada, Y. Matsumoto, S. Komukai, T. Kuge, T. Kawasaki, T. Matsuki, D. Motooka, K. Tsujino, M. Miki, K. Miki, S. Nakamura, H. Kida, Serum GPL core antibody levels are associated with disease activity and treatment outcomes in Mycobacterium avium complex lung disease following first line antibiotic treatment. Respir Med. 187, 106585 (2021).

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M. Inoue, S. Noguchi, K. Sonehara, K. Nakamura-Shindo, A. Taniguchi, H. Kajikawa, H. Nakamura, K. Ishikawa, M. Ogawa, S. Hayashi, Y. Okada, S. Kuru, A. Iida, I. Nishino, A recurrent homozygous ACTN2 variant associated with core myopathy. Acta Neuropathol. 142, 785–788 (2021).

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H. Kaida, K. Kitajima, M. Nakajo, M. Ishibashi, T. Matsunaga, R. Minamimoto, K. Hirata, K. Nakatani, A. Hung, S. Hattori, T. Yasuda, K. Ishii, Predicting tumor response and prognosis to neoadjuvant chemotherapy in esophageal squamous cell carcinoma patients using PERCIST: a multicenter study in Japan. Eur J Nucl Med Mol Imaging. 48, 3666–3682 (2021).

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T. Nakahama, Y. Kawahara, Deciphering the Biological Significance of ADAR1-Z-RNA Interactions. Int J Mol Sci. 22, 11435 (2021).

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S. Sakaue, M. Kanai, Y. Tanigawa, J. Karjalainen, M. Kurki, S. Koshiba, A. Narita, T. Konuma, K. Yamamoto, M. Akiyama, K. Ishigaki, A. Suzuki, K. Suzuki, W. Obara, K. Yamaji, K. Takahashi, S. Asai, Y. Takahashi, T. Suzuki, N. Shinozaki, H. Yamaguchi, S. Minami, S. Murayama, K. Yoshimori, S. Nagayama, D. Obata, M. Higashiyama, A. Masumoto, Y. Koretsune, FinnGen, K. Ito, C. Terao, T. Yamauchi, I. Komuro, T. Kadowaki, G. Tamiya, M. Yamamoto, Y. Nakamura, M. Kubo, Y. Murakami, K. Yamamoto, Y. Kamatani, A. Palotie, M. A. Rivas, M. J. Daly, K. Matsuda, Y. Okada, A cross-population atlas of genetic associations for 220 human phenotypes. Nat Genet. 53, 1415–1424 (2021).

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H. Shigemitsu, T. Tamemoto, K. Ohkubo, T. Mori, Y. Osakada, M. Fujitsuka, T. Kida, A cyanine dye based supramolecular photosensitizer enabling visible-light-driven organic reaction in water. Chem Commun (Camb). 57, 11217–11220 (2021).

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K. Torii, Y. Okada, A. Morita, Determining the immune environment of cutaneous T-cell lymphoma lesions through the assessment of lesional blood drops. Sci Rep. 11, 19629 (2021).

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J. Lim, E. Sakai, F. Sakurai, H. Mizuguchi, miR-27b antagonizes BMP signaling in early differentiation of human induced pluripotent stem cells. Sci Rep. 11, 19820 (2021).

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S. Hattori, X.-H. Zhou, Summary concordance index for meta-analysis of prognosis studies with a survival outcome. Stat Med. 40, 5218–5236 (2021).

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S. Takahashi, S. Usui, N. Hashida, H. Kubota, K. Nishida, H. Sakaguchi, K. Nishida, Multimodal imaging of indapamide-induced bilateral choroidal effusion: a case report. BMC Ophthalmol. 21, 386 (2021).

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E. Takai, W. Omata, Y. Totoki, H. Nakamura, S. Shiba, A. Takahashi, K. Namikawa, T. Mori, N. Yamazaki, T. Shibata, S. Yachida, Clonal dynamics of circulating tumor DNA during immune checkpoint blockade therapy for melanoma. Cancer Sci. 112, 4748–4757 (2021).

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S. Uematsu, H. Sakaguchi, K. Sayanagi, Y. Ikuno, A. Yokoyama, T. Asai, Y. Fukushima, C. Hara, S. Sakimoto, K. Nishida, Association between choriocapillaris flow deficit and choroidal neovascularization activity in eyes with myopic choroidal neovascularization. Sci Rep. 11, 21947 (2021).

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Y. Nakanishi, S. Kang, A. Kumanogoh, Neural guidance factors as hubs of immunometabolic cross-talk. Int Immunol. 33, 749–754 (2021).

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Y. Abe, Y. Suga, K. Fukushima, H. Ohata, T. Niitsu, H. Nabeshima, Y. Nagahama, H. Kida, A. Kumanogoh, Advances and Challenges of Antibody Therapeutics for Severe Bronchial Asthma. Int J Mol Sci. 23, 83 (2021).

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M. Al Kadi, E. Ishii, D. T. Truong, D. Motooka, S. Matsuda, T. Iida, T. Kodama, D. Okuzaki, Direct RNA Sequencing Unfolds the Complex Transcriptome of Vibrio parahaemolyticus. mSystems. 6, e0099621 (2021).

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